Drug combination therapy increases successful drug repositioning
نویسندگان
چکیده
منابع مشابه
Drug combination therapy increases successful drug repositioning.
Repositioning of approved drugs has recently gained new momentum for rapid identification and development of new therapeutics for diseases that lack effective drug treatment. Reported repurposing screens have increased dramatically in number in the past five years. However, many newly identified compounds have low potency; this limits their immediate clinical applications because the known, tol...
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Objective Drug repositioning is a promising methodology for reducing the cost and duration of the drug discovery pipeline. We sought to develop a computational repositioning method leveraging annotations in the literature, such as Medical Subject Heading (MeSH) terms. Methods We developed software to determine significantly co-occurring drug-MeSH term pairs and a method to estimate pair-wise ...
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ژورنال
عنوان ژورنال: Drug Discovery Today
سال: 2016
ISSN: 1359-6446
DOI: 10.1016/j.drudis.2016.05.015